A 5- year study of more than 1,000 people at high risk for recurring non-melanoma skin cancers such as basal cell and squamous cell will find out if vitamin A cream can prevent the development of new skin cancers. Previous studies have shown that in people with a genetic predisposition to certain skin cancers, high doses of vitamin A-related drugs taken internally can slow the development of skin cancers. But side effects such as bone and joint pain are often intolerable says researchers. The cream under study is tretinoin, which is now used to treat acne and reverse minor skin wrinkles. Some doctors says tretinoin is thought to interrupt the process that converts sun-damaged skin cells into cancerous cells. People in the study have already had at least two occurrences of basal or squamous cell cancers in the past 5 years, and they will use the cream in conjunction with sunscreen.